Type A adverse drug reaction

An adverse drug reaction (ADR) related to the pharmacological action of the drug. As a result, these ADRs are dose-dependent, and are predictable. They are sometimes referred to as “on-target side effects” since the side-effects result from the drug having an action at the intended target, where the magnitude of the action was greater than desired. This may result from a deliberate or inadvertent overdose (for example, a “normal” drug dose given to a patient who has reduced clearance for the drug). The incidence of type A adverse reactions, which occur far more often than type B adverse drug reactions, can be reduced through improved training of healthcare professionals in the principles of ADME.