62 Neutrophil Hyposegmentation
Valentin Villatoro and Michelle To
Hyposegmentation
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- An image from a peripheral blood smear showing a mildly hypogranular and hyposegmented neutorphil. Note the mature cytoplasm colour and nuclear chromatin pattern. 100x oil immersion. From MLS Collection, University of Alberta, https://doi.org/10.7939/R30863M82
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- An image from a peripheral blood smear showing a unilobed (hyposegmented) neutrophil. 100x oil immersion. From MLS Collection, University of Alberta, https://doi.org/10.7939/R3JW8733H
If there are many mature granulocytes that have a nucleus with less than 3 lobes, they are considered to be hyposegmented.1 The term “Pelger Huet” or “Pseudo Perlget Huet” may also be used depending on the context.
Related Conditions:2
Pelger-Huet Anomaly
Pseudo-Pelger-Huet Anomaly
References:
1. Landis-Piwowar K. Granulocytes and Monocytes. In: Clinical laboratory hematology. 3rd ed. New Jersey: Pearson; 2015. p. 97-121.
2. Rodak BF, Carr JH. Nuclear and cytoplasmic changes in leukocytes. In: Clinical hematology atlas. 5th ed. St. Louis, Missouri: Elsevier Inc.; 2017. p. 131-38.
