68 May-Hegglin Anomaly

Michelle To and Valentin Villatoro

PBS Key Features:1-4

Graunulocyte and Monoyte cytoplasms contain large basophilic inclusions that resemble Dohle bodies but are much larger and elongated. Inclusions are composed of precipitated myosin heavy chains.


Giant platelets and thrombocytopenia are also associated with this anomaly.



MYH9 gene mutation


Inheritance Pattern:1,5

Autosomal dominant


Clinical Significance:1-3,5

May-Hegglin anomaly is a platelet disorder that can cause mild bleeding tendencies but majority of patients are asymptomatic. Degree of bleeding is correlated to the degree of thrombocytopenia. Leukocyte function is unaffected.



Variable thrombocytopenia


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5. Landis-Piwowar K. Nonmalignant disorders of leukocytes: granulocytes and monocytes. In: Clinical laboratory hematology. 3rd ed. New Jersey: Pearson; 2015. p. 388-407.


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May-Hegglin Anomaly Copyright © 2019 by Michelle To and Valentin Villatoro is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License, except where otherwise noted.

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