83 Introduction to Myeloproliferative Neoplasms (MPNs)
Michelle To and Valentin Villatoro
MPNs are a group of clonal disorders that involve the proliferation and accumulation of one or more myeloid cell lines (erythrocytes, granulocytes, or platelets). These disorders are caused by genetic mutations in hematopoietic stem cells.1,2
MPNs are commonly seen in middle age adults but some may occur during childhood.1
The 2008 WHO classification system lists the following disorders under this category:1
Chronic Myelogenous Leukemia (CML)
Polycythemia Vera (PV)
Essential Thrombocytopenia (ET)
Primary Myelofibrosis (PMF)
Note: WHO 2008 lists additional disorders under MPNs but only the ones listed above will be discussed in this eBook.
1. Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, et al. editors. WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues Volume 2. 4th ed. International Agency for Research on Cancer (IARC); 2008.
2. Randolph TR. Myeloproliferative Neoplasms. In: Clinical laboratory hematology. 3rd ed. New Jersey: Pearson; 2015. p. 450-78.